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Oocyte Cryopreservation: Slow Cooling Versus Vitrification Techniques on Oocyte Survival

NCT00602966 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2011-10-28

No results posted yet for this study

Summary

Oocyte cryopreservation has been studied for many years without much success in refining a method that has consistent, reliable results in producing viable embryos and clinical pregnancies. In 1986 the first baby was born from an embryo created from a frozen oocyte; however, since then there have been less than 150 births from frozen eggs. To date, there are no reportable adverse outcomes in the children born from frozen oocytes. The research continues to look at different methods of oocyte cryopreservation. Many smaller studies have been conducted with some success but larger clinical trials are needed to replicate these findings. The conventional cryopreservation technique has been slow cooling with differing methods of freezing; however, vitrification is now being researched as the potential cryopreserving method that holds some promise for the future.

Our hypothesis is the use of vitrification (quick freezing) to cryopreserve oocytes in patients undergoing in-vitro fertilization will be more successful than slow freezing in oocyte survival, fertilization rate with ICSI and subsequent embryo development, implantation rate and pregnancy rate.

Conditions

Sponsors & Collaborators

  • EMD Serono

    collaborator INDUSTRY

  • UConn Health

    lead OTHER

Principal Investigators

  • Claudio Benadiva, MD, HCLD · The Center for Advanced Reproductive Services, P.C.

Eligibility

Min Age
21 Years
Max Age
36 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2009-10-31
Completion
2010-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00602966 on ClinicalTrials.gov