MedTrace Logo

Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence

NCT02793752 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-08-11

No results posted yet for this study

Summary

The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing. The aging process is complex and includes impaired mitochondrial dysfunction, oxidative stress, diminished metabolic activity, and activity of several cell-signaling systems. Cumulus cells form an intimate association with the oocyte in the follicle, and they can have a significant impact on oocyte meiotic and developmental competence. In the IVF lab, the clump of cumulus cells is typically cut away from the oocyte immediately after an oocyte retrieval procedure, and then the cumulus cells are discarded. Measuring the mitochondrial respiratory activity of cumulus cells may serve as a non-invasive biomarker for oocyte competency and a predictor of reproductive success in IVF patients in the future.

Conditions

Interventions

OTHER

Age

Maternal Age

Sponsors & Collaborators

  • Main Line Fertility Center

    lead OTHER

Principal Investigators

  • Sharon H Anderson, PhD · Main Line Fertility Center

Eligibility

Min Age
21 Years
Max Age
42 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2017-02-28
Completion
2017-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02793752 on ClinicalTrials.gov