The Lupus prEGnAnCY Cohort: An International Prospective Cohort of Lupus Pregnancies

Summary

The goal is to evaluate adverse pregnancy outcomes (APO), their predictors and potential preventive therapies, such as aspirin (ASA). The investigator aims to improve the outcomes for women with SLE and offsprings. By quantifying the risk of APO conferred by clinical risk factors that can be assessed early in pregnancy (i.e. first trimester), health professionals could be better equipped to estimate the individual risk of SLE pregnancies and the need for heightened surveillance and guide counseling for prophylactic measures, including ASA. Moreover findings from this study could eventually lead to the choice and weighting of first trimester clinical factors in future clinical prediction models for APO in SLE. The investigator's research efforts will improve reproductive health of SLE women, "mitigating the damage, functional loss, and disability that result from a chronic inflammatory disorder", such as SLE.

Conditions

• Systemic Lupus Erythematosus
• Pregnancy Complications

Sponsors & Collaborators

• Duke University

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• Dalhousie University

  collaborator OTHER

• Hanyang University

  collaborator OTHER

• Hospital for Special Surgery, New York

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• Monash University

  collaborator OTHER

• New York University

  collaborator OTHER

• Oklahoma Medical Research Foundation

  collaborator OTHER

• University of North Carolina

  collaborator OTHER

• Temple University

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• University of Birmingham

  collaborator OTHER

• University of Calgary

  collaborator OTHER

• University of California

  collaborator OTHER

• University of Copenhagen

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• University of Toronto

  collaborator OTHER

• NYU Langone Health

  collaborator OTHER

• University of British Columbia

  collaborator OTHER

• National Institute of Medical Science & Nutrition

  collaborator UNKNOWN

• Laval University

  collaborator OTHER

• University Health Network, Toronto

  collaborator OTHER

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  lead OTHER

Principal Investigators

• Evelyne Vinet, MD/PhD · Research Institute of the McGill University Health Centre

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-06-06

Primary Completion

2023-10-30

Completion

2024-01-30

Countries

• Canada

Study Locations