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Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure

NCT05679206 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 900

Last updated 2024-05-09

No results posted yet for this study

Summary

The primary goal of this observational study is to learn about postpartum pulmonary artery pressure in women who suffered from Preeclampsia and Antiphospholipid Syndrome.

The main question it aims to answer is whether the conjunction of preeclampsia with obstetric antiphospholipid syndrome significantly foster the development of long-lasting pulmonary hypertension.

Only participants who suffered from preeclampsia during pregnancy will be followed for a period up to 3 years postpartum. Researchers will compare women with or without obstetric antiphospholipid syndrome.

Conditions

  • Pre-Eclampsia; Complicating Pregnancy
  • Antiphospholipid Syndrome in Pregnancy
  • Pulmonary Hypertension

Interventions

DIAGNOSTIC_TEST

Echocardiography images

Transthoracic echocardiographic (Vivid E95) performed in all included patients between three months and three years after delivery. * Left ventricular ejection fraction, * Left ventricular mass index, * Septal and lateral mitral annular E-wave velocity assessed by tissue Doppler, * Tricuspid annular plane systolic excursion, * Left atrial volume index, * Right ventricle to right atrium (RV/RA) gradient

DIAGNOSTIC_TEST

24-hour ambulatory blood pressure monitoring

Twenty-four-hour ABPM performed between three months and three years after delivery using validated recorders (Spacelabs model 90217, USA)

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Emrush Rexhaj, MD · Insel Gruppe AG, Inselspital, Bern

Eligibility

Min Age
16 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-20
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05679206 on ClinicalTrials.gov