BioNTech presented phase 2 data for HER2-directed ADC Trastuzumab Pamirtecan showing 47.9% response rate in endometrial cancer, with FDA submission planned for 2026. BioLineRx dosed first patient in phase 1/2a GLIX1 trial for glioblastoma and reported new preclinical data. Both companies presented at ASCO 2026.
Anirban Maitra highlighted a talk at NYU Langone Health on milestones in developing RAS tricomplex inhibitors. The presentation also covered ongoing and planned combination approaches.
A large long-term NIH-funded trial found that older adults who practiced visual speed training were 25% less likely to develop Alzheimer's disease or other dementias even 20 years later, marking the first randomized clinical trial to assess such long-term links.
Researchers report advances in cancer treatment through three distinct approaches: repurposing a heart medication to target lymphoma enzymes, blocking stress proteins to enhance immunotherapy, and developing antibodies that restore immune system attacks on tumors.
Researchers discovered that lipocalin 2 (LCN2), a protein released by stressed cancer cells, helps lung and pancreatic tumors evade the immune system by manipulating macrophages and blocking T cell infiltration.
NYU Langone Health researchers discover pancreatic cancer cells toggle between rapid growth and chemotherapy resistance based on their proximity to extracellular matrix fibers, complicating single-drug treatment approaches.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07612215 |
Elacestrant in Advanced Triple Positive Breast Cancer |
RECRUITING | PHASE1/PHASE2 |
| NCT07607938 |
Psilocybin as a Novel Therapy for Residual Anhedonia |
NOT_YET_RECRUITING | PHASE1 |
| NCT07607522 |
Cardiac Rehab Referral Nudges |
NOT_YET_RECRUITING | |
| NCT07602517 |
Guselkumab for Overlap Inflammatory Bowel Disease and Spondyloarthritis |
NOT_YET_RECRUITING | |
| NCT07601828 |
Oxygen Delivery Index (ODIN) Study |
NOT_YET_RECRUITING | NA |
| NCT07598357 |
Salvaged Red Blood Cell Transfusion During Pancreatic Adenocarcinoma Operations |
NOT_YET_RECRUITING | NA |
| NCT07586241 |
Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA) |
NOT_YET_RECRUITING | |
| NCT07572526 |
tDCS: Sleep to Mood in Depression (S2M-D) |
NOT_YET_RECRUITING | NA |
| NCT07571239 |
Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI |
NOT_YET_RECRUITING | NA |
| NCT07567027 |
Improving Cryoablation Efficacy With BARRigel Rectal Spacing (ICE-BARR) |
NOT_YET_RECRUITING | NA |
