MedTrace Logo

Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma

NCT03620422 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2020-02-17

No results posted yet for this study

Summary

The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing reproducibly in mild allergic asthmatics compared with healthy controls and if salbutamol can affect this. Phase 1 of this study is a reproducibility analysis of cough dose response to mannitol in a cohort of mild allergic asthmatics and healthy controls. Phase 2 is a double-blind, placebo-controlled analysis in mild allergic asthmatics assessing the effects of salbutamol on mannitol induced cough.

Conditions

Interventions

OTHER

Mannitol

Mannitol-Induced Cough Challenge

DRUG

Salbutamol 5mg/mL

Nebulized salbutamol given prior to Mannitol-Induced Cough Challenge

OTHER

Sodium Chloride 0.9% Inhl 3Ml

Nebulized 0.9% saline given prior to Mannitol-Induced Cough Challenge

Sponsors & Collaborators

  • Syntara

    collaborator INDUSTRY

  • AllerGen NCE Inc.

    collaborator INDUSTRY

  • McMaster University

    lead OTHER

Principal Investigators

  • Gail Gauvreau, PhD · McMaster University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-11
Primary Completion
2020-01-31
Completion
2020-01-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03620422 on ClinicalTrials.gov