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The Effects of Salbutamol on Mannitol Induced Cough Responses in Healthy Controls

NCT04565847 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2022-06-16

No results posted yet for this study

Summary

The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing healthy controls with no evidence of bronchoconstriction (PC20\>16mg/ml or mannitol PD15 \> 635 mg, or \< 10% incremental fall in FEV1 between consecutive mannitol doses) and if salbutamol can affect this. This is a double-blind, placebo-controlled analysis in healthy controls assessing the effects of salbutamol on mannitol induced cough.

Conditions

Interventions

DRUG

Salbutamol 5mg/mL

Nebulized salbutamol given prior to Mannitol-Induced Cough Challenge

DRUG

Sodium Chloride 0.9% Inhl 3Ml

Nebulized 0.9% saline given prior to Mannitol-Induced Cough Challenge

Sponsors & Collaborators

Principal Investigators

  • Gail Gauvreau, PhD · McMaster University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-30
Primary Completion
2021-12-16
Completion
2021-12-16

Countries

  • Canada

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04565847 on ClinicalTrials.gov