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Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness

NCT01642745 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2016-10-27

No results posted yet for this study

Summary

The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.

Conditions

Interventions

DRUG

Methacholine (Provocholine)

two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL

DRUG

Mannitol (Aridol)

single deep inhalation of dry powder per dose doses range from 0mg - 160mg (cumulative dose range 0mg-635mg).

DRUG

Methacholine (Provocholine)

two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL every 20 seconds a deep inhalation is performed

Sponsors & Collaborators

  • University of Saskatchewan

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-11-30
Primary Completion
2013-02-28
Completion
2013-02-28

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01642745 on ClinicalTrials.gov