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Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol

NCT03105843 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-03-20

No results posted yet for this study

Summary

The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough.

We hypothesize:

1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls.
2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).

Conditions

Interventions

DRUG

Methacholine (MCh) Challenge Testing

Visit 1: Informed consent, Baseline screening and pulmonary function tests and Low-dose methacholine challenge testing using partial and full flow-volume loops.

DIAGNOSTIC_TEST

Eucapneic Voluntary Hyperventilation (EVH)

Visit 2 or 3: Will be conducted in random order and subjects will perform one of the two challenge tests at either visit.

DRUG

Mannitol Inhalation Kit

Visit 2 or 3: Will be conducted in random order and subjects will perform one of the two challenge tests at either visit.

Sponsors & Collaborators

  • Dr. Diane Lougheed

    lead OTHER

Principal Investigators

  • M. Diane Lougheed, MD, MSc · Department of Medicine, Queen's University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2026-06-01
Completion
2026-06-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03105843 on ClinicalTrials.gov