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Anesthetic Methods and Gene Expression Profile

NCT03585647 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 99

Last updated 2019-04-17

No results posted yet for this study

Summary

The study will analyze differentially regulated genes involved in oxidative stress and toxicology in peripheral blood mononuclear cells (PBMCs) of patients who underwent arthroplasty under three different anesthetic methods. The investigator hypothesized that anesthesia procedures trigger toxicity, thus inducing changes in the messenger ribonucleic acid (mRNA) profile. The results may provide a more profound understanding of the molecular mechanism of anesthesia and in overcoming the adverse effects arising from their use.

Conditions

  • Hip Arthroplasty

Interventions

PROCEDURE

hip arthroplasty

Hip replacement is a surgery for people with severe hip damage. The most common cause of damage is osteoarthritis.

Sponsors & Collaborators

  • University of Bologna

    lead OTHER

Principal Investigators

  • Battista Borghi, MD · Rizzoli Orthopaedic Institute

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-09-15
Primary Completion
2015-06-20
Completion
2016-11-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03585647 on ClinicalTrials.gov