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Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

NCT00854178 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2010-01-06

No results posted yet for this study

Summary

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

Conditions

  • Patients in Good Health
  • Types of General Anesthesia
  • DNA Damage

Interventions

DRUG

Comparison of two anesthetic drugs

Isoflurane 1,0 minimum alveolar concentration Propofol 2mg/kg and 4ug/ml

Sponsors & Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

    collaborator OTHER_GOV

  • UPECLIN HC FM Botucatu Unesp

    lead OTHER

Principal Investigators

  • Mariana G Braz, MsC · Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-03-31
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00854178 on ClinicalTrials.gov