MedTrace Logo

Neurotensin - an Important Regulator of Appetite in Humans?

NCT03522792 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2019-11-12

No results posted yet for this study

Summary

Neurotensin (NT) is a gut peptide released postprandially from the small intestine. It is known to exert a range of enterogastrone effects and in animal models it reduces food intake when administered by parenteral routes.

This study investigates whether the anorexic effects of NT suggested by animal studies can be translated.

Conditions

  • Physiology - Regulation of Appetite and Food Intake

Interventions

OTHER

Neurotensin

Intravenous infusion of neurotensin

OTHER

Saline

Intravenous infusion of saline

OTHER

Ad libitum meal

Participants will be served a large meal serving. They will be instructed to eat until they do not feel hungry anymore.

OTHER

Liquid meal

A standardized mixed liquid meal will be ingested to stimulate endogenous peptide hormone release

Sponsors & Collaborators

  • Copenhagen University Hospital, Hvidovre

    collaborator OTHER

  • University of Copenhagen

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-05
Primary Completion
2019-05-01
Completion
2019-12-01

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03522792 on ClinicalTrials.gov