Identifying the Neural Basis of Capability for Suicide
NCT03327129 · Status: SUSPENDED · Type: OBSERVATIONAL · Enrollment: 90
Last updated 2026-02-27
Summary
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system. The goal of the proposed research is to identify the neural network underlying capability for suicide in order to determine if it can be a target for identifying high-risk individuals and for intervention.
Conditions
- Major Depressive Disorder
- Suicide
- Suicidal Ideation
- Psychiatric Illness
Interventions
- PROCEDURE
-
fMRI
An fMRI scan will be conducted to collect neuroimaging data. The scanning session will consist of a structural MRI, followed by resting state and task-based functional MRI protocol.
Sponsors & Collaborators
-
Unity Health Toronto
lead OTHER
Principal Investigators
-
Sakina Rizvi, PhD · Unity Health Toronto
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-01-01
- Primary Completion
- 2025-04-01
- Completion
- 2028-09-30
Countries
- Canada
Study Locations
More Related Trials
-
Neuroimaging Sleep and Mood in Depression
NCT05497414 ·Status: UNKNOWN ·Phase: NA
-
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
NCT03321370 ·Status: RECRUITING
-
Molecular Imaging of Brain Inflammation in Depressive Disorders
NCT02983318 ·Status: COMPLETED
-
Neuroimaging Study for Decoding Emotional States and Identifying Neural Circuits to Disengage From Negative Thinking
NCT06254144 ·Status: COMPLETED
-
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
NCT06472622 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
The Role of Brain Activation and Cerebral Blood Flow in Mental Fatigue.
NCT03366233 ·Status: COMPLETED ·Phase: NA
-
Amotivational Syndrome and Fatigue in Neurosurgery
NCT04907513 ·Status: UNKNOWN
-
Altered Neural Pain Empathic Reactivity in NSSI Adolescents
NCT05968313 ·Status: RECRUITING
-
Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide
NCT02901769 ·Status: UNKNOWN ·Phase: NA
-
fMRI and Opioid Abstinence
NCT06651333 ·Status: RECRUITING
-
Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression
NCT02171923 ·Status: COMPLETED
-
Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study
NCT05811312 ·Status: RECRUITING
-
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
NCT06080646 ·Status: RECRUITING
-
Study of Functional Networks in Resting fMRI
NCT03323073 ·Status: TERMINATED ·Phase: NA
-
Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord
NCT03075254 ·Status: COMPLETED
-
Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress
NCT04060966 ·Status: COMPLETED
-
The Use of Resting State, fMRI and DTI in the Identification of Chronic Pain Conditions
NCT02987933 ·Status: UNKNOWN
-
Neuro- and Biofeedback in Nonsuicidal Self-injury
NCT05656001 ·Status: UNKNOWN ·Phase: NA
-
Brain Imaging of Psychotherapy for Depression
NCT00609453 ·Status: COMPLETED ·Phase: NA
-
Cognitive, Psychological and Electrophysiological Attributes to Suicide Among Depressed Patients
NCT04104698 ·Status: UNKNOWN
-
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
NCT06050070 ·Status: RECRUITING ·Phase: NA
-
A Potential Role for Oxygen in the Development of Mental Fatigue and the Subsequent Decline in Cognitive Performance
NCT05100667 ·Status: UNKNOWN ·Phase: NA
-
Simultaneous FMRI and NIRS to Estimate Brain Cerebral Metabolism
NCT01825096 ·Status: COMPLETED
-
Neural Bases of Motivation
NCT07251816 ·Status: RECRUITING ·Phase: NA
-
Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury
NCT01132937 ·Status: COMPLETED