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Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

NCT06080646 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2024-08-02

No results posted yet for this study

Summary

Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception, including individual variation in symptoms, severity, and treatment response. This heterogeneity complicates understanding of depression and thwarts progress toward disease classification and treatment planning. Discovery of depression-specific biomarkers that account for neurobiological variation that presumably underlies distinct clinical manifestations is critical to this larger effort.

Conditions

Interventions

OTHER

cross-sectional MRI and EEG assessments (NO INTERVENTION)

n/a there is no intervention in this observational study

Sponsors & Collaborators

  • San Francisco Veterans Affairs Medical Center

    lead FED

Principal Investigators

  • Susanna L Fryer, PhD · University of California, San Francisco

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-01
Primary Completion
2025-06-01
Completion
2025-09-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06080646 on ClinicalTrials.gov