NRx said the FDA outlined a path for a New Drug Application for NRX-100, a preservative-free ketamine formulation for depression with suicidality. The company plans to submit the NDA by June 2026 and said no additional nonclinical or bridging studies would be required.
Recent studies reveal AI chatbots face significant challenges in medical applications, with one study showing ChatGPT Health under-triaged 51.6% of emergency cases. Cancer patients using an AI chatbot experienced 22% withdrawal rates due to usability issues, while medical researchers show cautious adoption with 40.3% reporting AI use in research.
Bunnie Xo, wife of country star Jelly Roll, revealed she experienced suicidal thoughts while taking semaglutide, describing December 2025 as "one of the darkest times of my life." She emphasized the importance of discussing mental health side effects of weight-loss medications and encouraged others facing similar struggles to seek help.
Compass Pathways reports positive Phase 3 results for synthetic psilocybin in treatment-resistant depression, while a Phase 2 trial demonstrates rapid antidepressant effects from single-dose DMT. Both studies show modest efficacy signals amid growing pharmaceutical interest in psychedelic compounds.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07603986 |
CBT for Anger and Aggression in Children: a Pilot Study of Irritability and Suicidality |
COMPLETED | NA |
| NCT07569198 |
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) |
NOT_YET_RECRUITING | PHASE2 |
| NCT07568054 |
Neural Correlates of Suicidal Behavior in Youth |
NOT_YET_RECRUITING | NA |
| NCT07564583 |
Pilot Study of a Modified Safety Planning Intervention for Elementary School-Aged Children - Main Study |
ENROLLING_BY_INVITATION | NA |
| NCT07562191 |
Inhaled DMT for Major Depressive Disorder |
NOT_YET_RECRUITING | PHASE2 |
| NCT07534358 |
Intensive Case Management Between VA and Community Care for Suicide Prevention |
RECRUITING | NA |
| NCT07527052 |
Emerging Technologies and Teen Mental Health |
RECRUITING | NA |
| NCT07506525 |
Flourish in Schools Pilot Study |
RECRUITING | NA |
| NCT07484906 |
Precision Phenotyping of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies |
WITHDRAWN | PHASE2 |
| NCT07479823 |
A Text-Based Expressive Writing Program for Adolescents at Risk of Suicide |
NOT_YET_RECRUITING | NA |
