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Cerebral MRI During Sleep

NCT03304652 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 11

Last updated 2019-03-14

No results posted yet for this study

Summary

Recent studies in animal models have suggested a critical role for cerebrospinal fluid and Interstitial fluid flux through cerebral parenchyma for removal of byproducts of cellular metabolism and hence in maintaining the health of the brain. This effect is modulated during sleep, suggesting a potentially important mechanism for sleep to maintain both acute homeostasis and long-term cerebral health.

The central goal of these studies is to develop a sensitive MRI biomarker of cerebral conformational changes during sleep. This exploratory work aims to establish the sensitivity and reproducibility of MRI as a non-invasive neuroimaging assessment of cerebral changes during natural sleep and sedation.

Conditions

  • Sleep

Interventions

DRUG

Zaleplon

Sleep Aid; 10mg; Oral; Single Use

OTHER

Natural Sleep

Natural Sleep without medication

Sponsors & Collaborators

Eligibility

Min Age
18 Years
Max Age
59 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-01
Primary Completion
2018-10-31
Completion
2018-10-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03304652 on ClinicalTrials.gov