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Synaptic Injury and Functional Connectivity in Alzheimer's Disease

NCT03300726 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2021-09-28

No results posted yet for this study

Summary

The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with MCI (i.e. the earliest clinically detectable stage of cognitive impairment) due to AD or mild AD dementia (CDR 0.5-1; n=20) and cognitively normal controls (CDR 0; n=20).

Conditions

  • Alzheimer Disease, Late Onset

Interventions

DIAGNOSTIC_TEST

CSF analysis

CSF analysis for tau, p-tau181, Abeta42, and CSF levels of markers of synaptic injury

RADIATION

Functional MRI

Functional MRI during resting state and semantic memory task activation

Sponsors & Collaborators

  • Ohio State University

    lead OTHER

Principal Investigators

  • Rawan Tarawneh, MD · Ohio State University

Eligibility

Min Age
60 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-12
Primary Completion
2021-09-22
Completion
2021-09-22

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03300726 on ClinicalTrials.gov