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Chronic Insomnia and CSF Markers of Dementia

NCT04024020 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-01-23

Study results available
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Summary

The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years.The purpose of this study is to examine the relationship between chronic insomnia and dementia biomarkers and orexin levels found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia and age- and gender-matched good sleepers will undergo overnight polysomnography and CSF sampling in the morning.

Conditions

  • Insomnia Chronic

Interventions

OTHER

lumbar puncture

Subjects will have a lumbar puncture to collect cerebrospinal fluid collection

Sponsors & Collaborators

Principal Investigators

  • Philip Gehrman, PhD · University of Pennsylvania

Eligibility

Min Age
30 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2023-10-31
Completion
2023-10-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04024020 on ClinicalTrials.gov