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Sleep Aging and Risk for Alzheimer's 2.0

NCT03278119 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 158

Last updated 2026-03-30

No results posted yet for this study

Summary

Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will directly interrogate the brain using a 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at the 24-month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, the group that could profit the most from sleep preventive strategies.

Conditions

Interventions

DIAGNOSTIC_TEST

PET Scan and nocturnal polysomnography

Amyloid PET scans will be used to assess amyloid burden in the brain, and nocturnal polysomnography will be used to assess sleep and cardiopulmonary variables

Sponsors & Collaborators

Principal Investigators

  • Ricardo Osorio, MD · New York Langone Medical Center

Eligibility

Min Age
55 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-05-01
Primary Completion
2026-12-25
Completion
2026-12-25

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03278119 on ClinicalTrials.gov