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The Importance of Sleep Quality and the Blood-brain Barrier in Cognitive Disorders and Alzheimer's Disease

NCT04096261 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2022-07-27

No results posted yet for this study

Summary

The aim of our study is the analysis of sleep phases and quality as well as the detection of respiratory pauses in subjects with cognitive disorder. To assess whether sleep quality is associated with the blood-brain barrier and Alzheimer's disease, which may be indicative of an early, non-invasively measurable change in brain activity in the early stages of Alzheimer's disease.

Conditions

  • Blood Brain Barrier Defect
  • Sleep Deprivation
  • Sleep Apnea
  • Alzheimer Disease

Interventions

DIAGNOSTIC_TEST

Diagnostic Test

Diagnostic Test: Contrast agentenhanced MRI using Gadovist by using the contrast agent Gadovist we aim to visualize the blood-brain barrier. Furthermore, we aim to measure a newly developed biomarker of the blood-brain barrier in the cerebro-spinal fluid. And sleep quality measurement with a polysomnography.

Sponsors & Collaborators

  • Arda Can Cetindag

    collaborator UNKNOWN

  • Lukas Preis

    collaborator UNKNOWN

  • Charite University, Berlin, Germany

    lead OTHER

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-12
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04096261 on ClinicalTrials.gov