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Biorhythms in Metabolic Tissues

NCT03276442 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2017-10-12

No results posted yet for this study

Summary

Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are approximately 24 hours long ("circa diem"). These circadian rhythms exist both centrally, in the brain, but also in the periphery, and are specific to many tissues depending on their main biological function or functions. Whereas these circadian rhythms have been thoroughly characterized in other organisms, their role in humans remain poorly understood, partly because of the difficulty in studying these rhythms in peripheral tissues. The investigators therefore aim to characterize these rhythms in primarily skeletal muscle and adipose tissue in healthy young volunteers (using the so-called constant routine paradigm), and how these rhythms interact with one another at various genetic and molecular levels. At the same time, the investigators aim to study how an unhealthy vs. healthy diet can alter these circadian rhythms, and how they interact with circadian rhythms in other tissue compartments such as those expressed by blood cells.

Conditions

  • Sleep Deprivation
  • Metabolic Disturbance
  • Biological Clocks
  • Healthy

Interventions

OTHER

Low-fat dietary intervention

Low-fat diet (5-7 days) preceding extended wakefulness under standardized conditions

OTHER

High-fat dietary intervention

High-fat diet (5-7 days) preceding extended wakefulness under standardized conditions

Sponsors & Collaborators

  • The Swedish Research Council

    collaborator OTHER_GOV

  • Uppsala University

    lead OTHER

Principal Investigators

  • Jonathan Cedernaes · Uppsala University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
32 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-08-31
Primary Completion
2019-11-30
Completion
2019-12-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03276442 on ClinicalTrials.gov