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Sleep Deprivation's Regulation of Immune System Function and Behavior

NCT01730742 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2012-11-21

No results posted yet for this study

Summary

The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger. It is predicted that sleep deprivation will affect circulating neutrophil activity, and do so via affects on DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and down-regulate circulating oxytocin. Finally, it is predicted that sleep deprivation will increase participants' tendencies to pick larger portions of food, and also increase their tendency to purchase foods that are more caloric in a mock supermarket scenario.

Conditions

  • Sleep Deprivation
  • Sleep

Interventions

BEHAVIORAL

Neuroeconomics task

After a night of wakefulness, participants performed the neuroeconomics task (shopping food items in a mock supermarket scenario).

BEHAVIORAL

Portion Size Task

Participants are given a computer program that gives them the opportunity to choose the portions of a variety of food items that they would ideally like to consume

PROCEDURE

Blood sample

After a night of wakefulness, a blood sample was taken to assess the level and efficacy of circulating neutrophils, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as oxytocin and ghrelin

Sponsors & Collaborators

  • Uppsala University

    lead OTHER

Principal Investigators

  • Christian Benedict, PhD · dept. of Neuroscience, Uppsala University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01730742 on ClinicalTrials.gov