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Breath Biomarkers for Sleep Loss and Circadian Timing

NCT03980340 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2025-08-03

No results posted yet for this study

Summary

Insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency. The current study aims to use a cutting-edge technology, small molecule analysis (e.g. metabolomics), to detect compounds in breath that reliably change with sleep-wake state and those whose levels vary by time of day.

Conditions

  • Shift-Work Sleep Disorder
  • Shift Work Type Circadian Rhythm Sleep Disorder
  • Sleep Disorders, Circadian Rhythm
  • Sleep Disorders, Intrinsic
  • Advanced Sleep Phase Syndrome (ASPS)
  • Advanced Sleep Phase Syndrome
  • Advanced Sleep Phase
  • Delayed Sleep Phase
  • Delayed Sleep Phase Syndrome
  • Non-24 Hour Sleep-Wake Disorder
  • Irregular Sleep-Wake Syndrome

Interventions

BEHAVIORAL

Short Nap Intervention

Study participants may be asked to have a 1-2 hour nap in between the breath analysis tests.

BEHAVIORAL

No Nap Intervention

Study participants may be asked to sit or lay down remaining awake for 1-2 hours in between breath analysis tests.

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Jeanne F Duffy, MBA, PhD · Brigham and Women's Hospital

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-28
Primary Completion
2025-01-31
Completion
2025-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03980340 on ClinicalTrials.gov