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Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

NCT03255408 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2026-05-01

No results posted yet for this study

Summary

A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).

Conditions

  • Obstructive Sleep Apnea of Adult
  • Hypoxia, Brain
  • Sleep Apnea
  • Sleep Disorder
  • Stroke
  • Blood Pressure
  • Endothelial Dysfunction
  • Oxidative Stress

Interventions

DRUG

Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep

The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Normoxia Exposure

DRUG

Drug Lowering CBF and Intermittent Hypoxia Sleep

The study participants will take Cerebral Blood Flow (CBF) lowering drug and sleep under Intermittent Hypoxia (IH) Exposure

DRUG

Placebo and Normoxia Sleep

The study participants will take Placebo and sleep under Normoxia Exposure

DRUG

Placebo and Intermittent Hypoxia Sleep

The study participants will take Placebo and sleep under Intermittent Hypoxia (IH) Exposure

Sponsors & Collaborators

  • University of Calgary

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2027-12-30
Completion
2027-12-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03255408 on ClinicalTrials.gov