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Effects of Mild Hypobaric Hypoxia on Oxygen Saturation During Sleep

NCT00659009 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2012-08-15

No results posted yet for this study

Summary

Ascent to altitude lowers oxygen saturation. In addition, sleep lowers oxygen saturation at any altitude. In a prior study, we observed that sleep at 8000 feet resulted in pronounced reduction in oxygen saturation, but did not result in reduced post sleep neurobehavioral performance or impaired sleep quality or quantity. We plan to do a more sophisticated physiological evaluation of the respiratory mechanisms responsible for the reduced oxygen saturation and determine if there are any adverse consequences to this level of intermittent hypoxia. We anticipate that central respiratory apnea is the physiologic mechanism, and that there will not be persistent changes in autonomic nervous activity measured by heart rate variability.

Conditions

  • Sleep-related Respiratory Disturbance

Interventions

OTHER

Reduced barometric pressure

Sleep in reduced barometric pressure environment.

OTHER

Sea level equivalent barometric pressure

Sleep in barometric pressure equivalent to sea level.

OTHER

Reduced barometric pressure

Sleep in reduced barometric pressure environment.

Sponsors & Collaborators

  • Simon Fraser University

    collaborator OTHER

  • Massey University

    collaborator OTHER

  • The Boeing Company

    lead INDUSTRY

Principal Investigators

  • James M Muhm, MD, MPH · The Boeing Company

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
30 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2009-03-31
Completion
2009-03-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00659009 on ClinicalTrials.gov