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Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep

NCT00732199 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 92

Last updated 2017-06-28

Study results available
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Summary

The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly. This proposal focused on key factors that contribute to the control of ventilation in elderly adults during sleep. The investigators studied the age-specific changes in ventilatory control in older and young adults during NREM sleep.

Conditions

Interventions

OTHER

1) hyperventilation via noninvasive positive pressure ventilation 2) multiple trials of episodic hypoxia

1\) noninvasive hyperventilation to determine apneic threshold; 2) episodic hypoxia to determine ventilatory long term facilitation

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Susmita Chowdhuri, MD · John D. Dingell VA Medical Center, Detroit, MI

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2015-04-30
Completion
2015-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00732199 on ClinicalTrials.gov