MedTrace Logo

Immune-Competent Cell Manifestations in Psoriatic Arthritis Achilles Tendons

NCT03248284 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-12-05

No results posted yet for this study

Summary

Tendon pathologies (enthesitis) are a characteristic component of psoriatic arthritis (PsA), and are observed in 35% to 50% of PsA patients. The Achilles tendon is one of the most commonly affected sites. This condition often causes great morbidity and loss of quality of life, and response only suboptimal to current intervention strategies. One of the main obstacles for the development of effective treatment methods is that the disease mechanisms remain poorly understood. To our knowledge, no one has yet ascertained the presence and function of immune-competent cells and inflammatory markers in tendons tissue from PsA patients suffering from Achilles enthesitis.

Conditions

Interventions

PROCEDURE

Tendon biopsy procedure

Two tendon biopsy specimens will be obtained from one Achilles tendon with enthesitis.

Sponsors & Collaborators

  • University of Southern Denmark

    collaborator OTHER

  • Odense Patient Data Explorative Network

    collaborator OTHER

  • The Danish Rheumatism Association

    collaborator OTHER

  • The Psoriasis Association, Denmark

    collaborator UNKNOWN

  • Odense University Hospital

    lead OTHER

Principal Investigators

  • Maja S Kragsnaes, MD PhDfellow · Odense University Hospital

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-21
Primary Completion
2026-12-31
Completion
2027-03-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03248284 on ClinicalTrials.gov