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Biomarker Signature and Musculoskeletal Ultrasound Profile in Rheumatoid Arthritis Patients

NCT02476084 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2022-05-20

No results posted yet for this study

Summary

The purpose of this study is to determine the kinetics of change in quantitative measures of joint inflammation by state of the art power Doppler vascular imaging and to identify biomarkers in biological samples (synovial biopsies, DNA, RNA, PBMC, serum, plasma, urine and stool samples) from parallel cohorts of RA patients undergoing different treatments. This will be achieved implementing MSUS assessments, standard laboratories techniques (such as ELISAs, gene profiling, transcriptome analysis etc.) and the novel CyTOF™ technology.

Conditions

Interventions

OTHER

Musculoskeletal Ultrasound Imaging

B-mode and PD musculoskeletal ultrasound examination of selected joints.

OTHER

Synovial biopsy

US guided synovial biopsy of an inflamed joint including wrists, MCP joints and knees.

OTHER

Biological samples collection

Draw of research blood samples.

OTHER

Questionnaires

Administration of validated patients' questionnaires.

Sponsors & Collaborators

  • UCB Pharma

    collaborator INDUSTRY

  • University of Oxford

    lead OTHER

Principal Investigators

  • Peter C Taylor, PhD, FRCP · Kennedy Institute of Rheumatology, University of Oxford

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-10-13
Primary Completion
2021-10-01
Completion
2021-10-01

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02476084 on ClinicalTrials.gov