Retinal Imaging in Neurodegenerative Disease

Summary

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Conditions

• Alzheimer's Disease
• Mild Cognitive Impairment
• Parkinson's Disease
• Multiple Sclerosis
• Huntington Disease
• Lewy Body Dementia
• Frontotemporal Dementia
• Amyotrophic Lateral Sclerosis (ALS)
• APOE-4 Positive
• Traumatic Brain Injury
• Concussion
• Post-Traumatic Stress Disorder
• Down Syndrome
• Neuro-Degenerative Disease
• Normal Cognition

Interventions

DEVICE

Retinal and Choroidal Imaging

Non-invasive OCT, OCTA, and UWF fundus photography of retina

Sponsors & Collaborators

• University of Edinburgh in Scotland

  collaborator UNKNOWN

• Tan Tock Seng Hospital in Singapore

  collaborator UNKNOWN

• Queens University of Belfast United Kingdom

  collaborator UNKNOWN

• Duke University

  lead OTHER

Principal Investigators

• Sharon Fekrat, MD FACS FASRS · Duke University

• Dilraj Grewal, MD · Duke University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-07-20

Primary Completion

2026-12-31

Completion

2026-12-31

FDA Device

Yes

Countries

• United States

Study Locations