Retinal and Cognitive Dysfunction in Type 2 Diabetes

Summary

The retina shares similar embryologic origin, anatomical features and physiological properties with the brain and hence offers a unique and accessible "window" to study the correlates and consequences of subclinical pathology in patients with cognitive impairment. Our hypothesis is that the neurodegeneration of the retina will run in parallel to the neurodegeneration of the brain and, therefore, the signs of neurodysfunction in the retinal assessment will be more evident in those patients with rapid cognitive decline. Microangiopathy will also participate in cognitive decline and its specific role, as well as usefulness of retinal imaging, will be also examined.

This is a multinational and multicentre cross-sectional study and prospective, longitudinal cohort observational study.

Conditions

• Retinal Function
• Cognitive Dysfunction
• Microperimetry

Sponsors & Collaborators

• Queen's University, Belfast

  collaborator OTHER

• Association for Innovation and Biomedical Research on Light and Image

  collaborator OTHER

• UMC Utrecht

  collaborator OTHER

• University of Medical Centre Amsterdam

  collaborator UNKNOWN

• University of Rome Tor Vergata

  collaborator OTHER

• Ospedale San Raffaele

  collaborator OTHER

• University of Milan

  collaborator OTHER

• University of Southern Denmark

  collaborator OTHER

• Azienda Ospedaliero Universitaria Maggiore della Carita

  collaborator OTHER

• Hospital Mutua de Terrassa

  collaborator OTHER

• Institut Catala de Salut

  collaborator OTHER_GOV

• University of Montenegro

  collaborator OTHER

• Clinical Center of Montenegro

  collaborator OTHER

• University of Cadiz

  collaborator OTHER

• European Infrastructure for Translational Research

  collaborator UNKNOWN

• Alzheimer Europe

  collaborator OTHER

• International Diabetes Federation Europe

  collaborator UNKNOWN

• Anaxomics Biotech S.L.

  collaborator UNKNOWN

• Oxurion

  collaborator INDUSTRY

• Genesis Biomed

  collaborator UNKNOWN

• Hospital Universitari Vall d'Hebron Research Institute

  lead OTHER

Principal Investigators

• Noemi Lois, Prof. · Queen´s University Belfast

• Rafael Simó, Prof · Vall Hebron Research Institute-VHIR

Eligibility

Min Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-11-16

Primary Completion

2024-12-12

Completion

2024-12-31

Countries

• Spain

Study Locations