Traumatic brain injury is brain dysfunction caused by an external force such as a blow, jolt, or penetrating injury to the head. It ranges from mild to severe and can produce acute and long-term cognitive, physical, and behavioral impairments.
FDA final guidance sets standards for psychedelic clinical trials. Federal agencies and states are advancing psilocybin and ibogaine research, and Eli Lilly is acquiring AtaiBeckley for $2.8 billion.
Adjunct intra-arterial alteplase after thrombectomy improved 90-day functional recovery in LVO stroke (57.5% vs 42.5%). Headache occurs in 46% of hemorrhagic stroke patients; only 21.8% of stroke/TBI patients receive inpatient rehab.
A Cochrane review finds exercise for hip osteoarthritis reduces pain by 7 points on a 100-point scale, below the 12-point threshold for noticeable benefit. A survey shows 76% of physical therapy patients skip home exercises, citing forgetfulness and time constraints. A study reports only 22% of stroke and brain injury survivors receive intensive inpatient rehab, with disparities by race, insurance, and income.
NHMRC Tracker newsletters cover the new Research Translation Strategy 2026–2030, a revised generative AI policy, RRR Capacity Building grants, and consultations on drinking water and clinical guidelines.
Research and survey data point to lifelong learning, midlife stimulating activities and treatment of health risks as factors linked to better brain health and lower dementia risk.
Rhythm Pharmaceuticals announced expanded Phase 3 TRANSCEND trial data showing an 18.8% placebo-adjusted BMI reduction at 52 weeks for setmelanotide in acquired hypothalamic obesity, with FDA PDUFA goal date set for March 20, 2026.
Blood-based biomarkers including brain-derived tau and amyloid-beta are enabling earlier Alzheimer's disease diagnosis through non-invasive testing, though confirmatory imaging remains necessary before treatment initiation.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07780279 |
Diagnostic Accuracy of Bedside Optic Nerve Sheath Diameter Ultrasonography for Detecting Raised Intracranial Pressure Compared With Brain CT Findings in Children With Traumatic Brain Injury |
NOT_YET_RECRUITING | |
| NCT07772323 |
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury |
NOT_YET_RECRUITING | |
| NCT07768761 |
Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis |
RECRUITING | NA |
| NCT07759063 |
Clinical Validation of Self-Pacing Algorithms on Step Length Symmetry in Hemiplegic Populations |
ENROLLING_BY_INVITATION | NA |
| NCT07756060 |
Creatine Supplementation in Pediatric Brain Injury |
NOT_YET_RECRUITING | NA |
| NCT07749612 |
ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT) |
NOT_YET_RECRUITING | NA |
| NCT07747636 |
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care |
NOT_YET_RECRUITING | NA |
| NCT07741149 |
Self-Management Training Among Individuals With TBI |
NOT_YET_RECRUITING | NA |
| NCT07739264 |
ZEPU-SGI1PLUS Hand Training Study (ZEPUSGI1RCT) |
NOT_YET_RECRUITING | NA |
| NCT07733336 |
Home-Based Exergame Motor-Cognitive Rehabilitation for Traumatic Brain Injury |
NOT_YET_RECRUITING | NA |
