Traumatic brain injury is brain dysfunction caused by an external force such as a blow, jolt, or penetrating injury to the head. It ranges from mild to severe and can produce acute and long-term cognitive, physical, and behavioral impairments.
Research and survey data point to lifelong learning, midlife stimulating activities and treatment of health risks as factors linked to better brain health and lower dementia risk.
Rhythm Pharmaceuticals announced expanded Phase 3 TRANSCEND trial data showing an 18.8% placebo-adjusted BMI reduction at 52 weeks for setmelanotide in acquired hypothalamic obesity, with FDA PDUFA goal date set for March 20, 2026.
Blood-based biomarkers including brain-derived tau and amyloid-beta are enabling earlier Alzheimer's disease diagnosis through non-invasive testing, though confirmatory imaging remains necessary before treatment initiation.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07613918 |
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children |
NOT_YET_RECRUITING | |
| NCT07612410 |
Impact of Traumatic Brain Injury on Cognitive Function, Balance and Functional Independence in Children |
ACTIVE_NOT_RECRUITING | |
| NCT07604701 |
Examining the Efficacy of the Man Therapy Platform in Reducing Problematic Anger Among Military Service Members With and Without a TBI History |
NOT_YET_RECRUITING | NA |
| NCT07600320 |
Fareon Open Label Device Clinical Trial |
NOT_YET_RECRUITING | NA |
| NCT07557615 |
hCG Treatment for Rehabilitation From a TBI |
NOT_YET_RECRUITING | EARLY_PHASE1 |
| NCT07544602 |
Music Therapy for Comatose Brain Injured Patients |
NOT_YET_RECRUITING | |
| NCT07527949 |
PASTRAMI : Patient-specific Statistics for Microstructure-augmented Connectomics |
NOT_YET_RECRUITING | NA |
| NCT07521384 |
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy |
ENROLLING_BY_INVITATION | |
| NCT07510074 |
Modulating Inflammation in Neuro-Trauma |
NOT_YET_RECRUITING | NA |
| NCT07493889 |
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries |
COMPLETED | NA |
