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Acute Effects of Whole Body Blue Light Exposure on Blood Pressure

NCT03226587 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2017-11-09

No results posted yet for this study

Summary

Ultraviolet light exposure was shown to be able to release nitric oxide from the skin into the blood stream and lead to an acute decrease in blood pressure and increase in vascular function. Additionally, preliminary work indicates that UV free blue light also releases nitric oxide in the skin mediating similar effects as seen with ultraviolet light A(UVA). It is the goal of the present experimental study to investigate the hemodynamic effects of whole body blue light exposure including blood pressure, endothelial function and vascular stiffness. Therefore, healthy volunteers will be exposed to 30 minutes whole body blue light (453 nm wavelength) and the change in blood pressure and endothelial function (Flow mediated dilation (FMD)), heart rate, forearm-blood flow, forearm vascular resistance central blood pressure and vascular stiffness ( pulse wave analysis by sphygmocor) will be measured.

In this randomized controlled cross-over study, 20 healthy subjects aged 30 to 60 years will participate.

Conditions

  • Blue Light

Interventions

PROCEDURE

Blue light

Subjects will be exposed to blue light (453 nm wavelength) for 30 minutes

PROCEDURE

control exposure

Subjects will get control exposure to 30 minutes of whole body, which causes only comparable warming of skin as with blue light exposure.

Sponsors & Collaborators

  • Philips GmbH, Innovative Technologies, Aachen

    collaborator UNKNOWN

  • Klinik für Unfall - und Handchirurgie, Universitätsklinikum Düsseldorf

    collaborator UNKNOWN

  • Heinrich-Heine University, Duesseldorf

    lead OTHER

Principal Investigators

  • Christian Heiß, MD · Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Dusseldorf

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
30 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2017-08-31
Completion
2017-08-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03226587 on ClinicalTrials.gov