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Modulation of Metabolic Rate by Inorganic Nitrate

NCT02022176 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 55

Last updated 2014-01-03

No results posted yet for this study

Summary

The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.

Conditions

  • Resting Metabolic Rate

Interventions

OTHER

Glucose Uptake

Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp

OTHER

Resting metabolic rate

Resting metabolic rate is measured by indirect calorimetry after an over-night fast

OTHER

Nitrite infusion

Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion

Sponsors & Collaborators

  • The Swedish Research Council

    collaborator OTHER_GOV

  • Swedish Heart Lung Foundation

    collaborator OTHER

  • Karolinska Institutet

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-03-31
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • Sweden

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02022176 on ClinicalTrials.gov