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To Study the Effect of Sevoflurane and Propofol V Sevoflurane and Dexmedetomidine on Postoperative Cognitive Dysfunction

NCT03145714 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2019-02-04

No results posted yet for this study

Summary

Postoperative Cognitive Dysfunction (POCD), is a subtle decline in cognitive function characterized by impairment of memory and reduced ability to concentrate in elderly patients exposed to general anaesthesia. This prospective study aims to compare incidence and severity of POCD in two groups of patients. Group P receiving Intravenous Propofol and Inhalational anesthetic Sevoflurane. Group D receiving Intravenous Dexmedetomidine and Inhalational anesthetic Sevoflurane, Neuropsychological Test will be performed 24 hours before surgery and on postoperative day 3 and day 7.

Conditions

  • Postoperative Cognitive Dysfunction

Interventions

DRUG

Maintainance of anesthesia with Intravenous Propofol infusion

The dosage of Intravenous Propofol will be titrated to maintain BIS Values between 40 -60.

DRUG

Maintainance of anesthesia with Intravenous Dexmedetomidine

The dosage of Intravenous Dexmedetomidine will be titrated to maintain BIS Values between 40 -60.

Sponsors & Collaborators

  • Rajiv Gandhi Cancer Institute & Research Center, India

    lead OTHER

Principal Investigators

  • Anita Kulkarni, M.D. · Rajiv Gandhi Cancer Institue & Research Centre , Delhi, INDIA

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
58 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-01
Primary Completion
2018-02-10
Completion
2018-03-28

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03145714 on ClinicalTrials.gov