MedTrace Logo

Effect of Affective Content on Drug Induced Amnesia of Episodic Memory

NCT00142493 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 79

Last updated 2015-12-24

No results posted yet for this study

Summary

The purpose of this research is to understand how some of the drugs commonly used in anesthesia impair memory. We are particularly interested in whether the emotion associated with a memory influences how well these drugs are able to block memory. We are studying four commonly used drugs-propofol, thiopental, midazolam, and dexmedetomidine, all of which may have slightly differing effects. We will also study an inactive substance, called a placebo, that should have no effect. The results of this study will provide information that will be useful in understanding how memory works, how these drugs affect memory, and possibly why some people don't have their memory blocked as easily as others.

Conditions

  • Memory Losses
  • Amnesia-Memory Loss

Interventions

DRUG

Propofol

1.2ug/ml

DRUG

Thiopental Sodium

2.0ug/ml

DRUG

Dexmedetomidine Hydrochloride

0.5ng/ml

DRUG

Midazolam Hydrochloride

60ng/ml

DRUG

placebo

intralipid, saline, saline with multi-Vit solution

Sponsors & Collaborators

Principal Investigators

  • Kane O. Pryor, M.D. · Memorial Sloan Kettering Cancer Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-09-30
Primary Completion
2008-08-31
Completion
2008-08-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00142493 on ClinicalTrials.gov