MedTrace Logo

Long-term Outcome of General Anesthesia on Dysgnosia

NCT01184638 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 10000

Last updated 2014-01-14

No results posted yet for this study

Summary

Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.

Conditions

  • Delirium,
  • Dementia,
  • Amnestic,
  • Cognitive Disorders

Interventions

DRUG

Sevoflurane

1-8% sevoflurane for maintaining the whole period of general anesthesia

DRUG

Propofol

1-4 mg/kg/h of propofol during the whole period of general anesthesia

Sponsors & Collaborators

  • Nanjing Medical University

    lead OTHER

Principal Investigators

  • FuZhou Wang, PhD MD · Nanjing Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
10 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-08-31
Primary Completion
2020-08-31
Completion
2020-08-31

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01184638 on ClinicalTrials.gov