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Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

NCT02691416 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2017-07-11

Study results available
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Summary

The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.

Conditions

  • Cerebral Arterial Aneurysm

Interventions

DRUG

propofol postconditioning

administrated Target Controlled Infusion(TCI) of propofol (Cp 1.2ug/ml) and decreased sevoflurane with a Bispectral index (BIS) value of 40-60 to maintain anesthesia after clamp removal

DRUG

sevoflurane

0.5%-2% sevoflurane with BIS 40-60

Sponsors & Collaborators

  • The Third Central Clinical College of Tianjin Medical University

    lead OTHER

Principal Investigators

  • Haiyun Wang · The Third Central Clinical College of Tianjin Medical University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2015-12-31
Completion
2016-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02691416 on ClinicalTrials.gov