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MTNR1B SNP*Food Timing Interaction on Glucose Control

NCT03036592 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 889

Last updated 2025-04-16

Study results available
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Summary

The purpose of this investigation is to assess the role of melatonin receptor 1B (MTNR1B) single nucleotide polymorphism (SNP)\*food timing interaction on glucose control in the deleterious effect in a vulnerable population with regular exposure to concurrent high melatonin and food intake as late night eaters (those having dinner within 2.5 h before their usual bed time). With the results from this study, we expect to advance our understanding of the role of endogenous melatonin on glucose metabolism in late night eaters and carriers of the MTNR1B risk allele, with potential implications on the guidelines to mitigate risk of type 2 diabetes in late night eaters and carriers of the MTNR1B risk allele.

Conditions

  • Non-Diabetic Disorder of Endocrine Pancreas

Interventions

BEHAVIORAL

Early OGTT

Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)

BEHAVIORAL

Late OGTT

Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)

Sponsors & Collaborators

  • Universidad de Murcia

    lead OTHER

Principal Investigators

  • Purificación Gomez Abellan, PHD · Universidad de Murcia

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2020-03-13
Completion
2020-03-13

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03036592 on ClinicalTrials.gov