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Quantification of the Incretin Effect in Healthy Subjects and Patients With Type 2 Diabetes

NCT00529048 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 16

Last updated 2009-10-20

No results posted yet for this study

Summary

Patients with T2DM lac a sufficient incretin response after oral glucose intake. It has only been tested using 50g of glucose. We don't know if patients with T2DM are capable of regulating the incretin effect like healthy people in responds to different amounts of glucose intake.

The aim of the present study is to quantify the incretin effect in healthy subjects and in patients with T2DM during increasing amounts of oral glucose challenges. The proposed studies will answer important questions on the mechanisms underlying T2DM and be of importance in relation to future preventive- and treatment strategies.

Conditions

  • Incretin Effect

Interventions

OTHER

Oral Glucose Tolerance Test

The test is preformed 3 times with 3 different amounts of glucose (25g, 75g and 125g) deluded in 300ml of water.

OTHER

Isoglycemic clamp

I.v. glucose infusion initiating the glucose responds curves from the OGTT

OTHER

Gastric emptying rate

Paracetamol absorption test. Intake of 1,5g of paracetamol followed by measuring the absorption curve

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Merck Sharp & Dohme LLC

    collaborator INDUSTRY

  • Forskningsrådet

    collaborator UNKNOWN

  • Diabetesforeningen

    collaborator OTHER

  • Herlev Hospital

    lead OTHER

Principal Investigators

  • Tina Villsbøll, MD.DMSc. · Herlev Hospital

  • Filip K Knop, MD.Phd. · Herlev Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-10-31
Completion
2009-09-30

Countries

  • Denmark

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00529048 on ClinicalTrials.gov