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GLP-1 and Oxyntomodulin Release in Relation to Diet in Type 2 Diabetes Patients.

NCT04105608 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2019-09-26

No results posted yet for this study

Summary

The aim of this trial was to assess glycemic control and incretin release in subjects affected by type-2 diabetes, a condition in which GLP-1 release is impaired. It is known that nutrition affects a variety of factors in overall quality of life in diabetes and we hypothesized incretin secretion may improve in acute. As little is known regarding oxyntomodulin secretion in relation to diet, we explored this gut-derived hormone behavior as well.

Hence, the administration of two meals was carried out; these were equal in terms of calories but different for macronutrients composition. Appetite rating was assessed as well through a 100-mm horizontal Visual Analogue Scale, either at fasting and for 4 hours once the meal was completed.

Conditions

  • Type-2 Diabetes

Interventions

DIETARY_SUPPLEMENT

High-fiber vegetarian meal

The intervention consisted in the administration of a high fiber vegetarian meal prepared by our research group staff.

DIETARY_SUPPLEMENT

Mediterranean-like meal

The intervention consisted in the administration of a Mediterranean-like meal prepared by our research group staff.

Sponsors & Collaborators

  • Antonio Di Mauro

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-01
Primary Completion
2017-12-01
Completion
2018-02-28

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04105608 on ClinicalTrials.gov