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Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart

NCT02885740 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2016-08-31

No results posted yet for this study

Summary

The purpose of this study is to analyze the association of atrial fibrillation onset in normal heart and:

* Genetic determinants (genes of receptors, enzymes involved in synthesis and degradation, genes of bioavailability of coenzymes and nutritional precursors)
* Metabolic determinants of adenosine and methionine cycles
* Nutritional determinants.

Secondary purposes are:

* Analysis of physiopathologic mechanisms of AF in normal hearts and adenosine metabolisms and its interaction with methionine metabolism, according to identified genetic determinants
* Analysis of blood markers of adenosine and methionine metabolites as phenotypic markers of detected polymorphisms
* Evaluate the role of adenosine receptors in AF onset

Conditions

Interventions

OTHER

Quantification assay of adenosine and methionine cycle metabolites

GENETIC

Polymorphism analysis of genes related to adenosine metabolism and methionine cycle

OTHER

Quantitative and qualitative nutritional evaluation

Questionnaire on consumption of 208 foods and drinks

BIOLOGICAL

Blood sample

Sponsors & Collaborators

  • Central Hospital, Nancy, France

    lead OTHER

Principal Investigators

  • Etienne ALIOT, Pr · Département de Cardiologie, CHU Nancy, Hôpitaux de Brabois, France

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2017-01-31
Completion
2017-10-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02885740 on ClinicalTrials.gov