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Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough

NCT02797756 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2019-01-29

No results posted yet for this study

Summary

Using an active cohort of children in whom Airway and gastrointestinal endoscopy will be performed, investigators will conduct a chart review to obtain relevant clinical data and the investigators will use an aliquot of airway sample obtained during the clinically indicated bronchoscopy for microbiome analysis. A case-control study design will be used to study whether subjects with CC with GER have a distinct lung microbiome and increased inflammation as compared with subjects with CC without GER and to determine whether the microbiome and degree of inflammation is related to the type of GER (acidic versus nonacidic).

Conditions

  • Chronic Cough (CC)
  • Gastroesophageal Reflux (GER)

Interventions

PROCEDURE

Esophago-gastro-duodenoscopy (EGD) with biopsy

PROCEDURE

Esophageal Impedance Monitoring (EIM)

Sponsors & Collaborators

Principal Investigators

  • Mikhail N Kazachkov, MD · New York University Medical School

Eligibility

Max Age
24 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-05
Primary Completion
2018-12-12
Completion
2018-12-12

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02797756 on ClinicalTrials.gov