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Cough Reflex Sensitivity and Bronchial Hyper-responsiveness

NCT01777867 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2017-02-17

No results posted yet for this study

Summary

The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of gastroesophageal reflux disease (GERD) and visceral acid hypersensitivity.

Conditions

  • Gastroesophageal Reflux Disease
  • Chronic Cough
  • Broncho-hyperreactivity

Interventions

PROCEDURE

Cough Reflex Sensitivity

Subjects inhaled increasing concentrations of citric acid, which induces coughing in a dose-dependent, reproducible matter. Following each inhalation, the number of coughs in the subsequent 15 seconds was counted and recorded. The challenge was terminated once the citric acid induced 5 or more coughs and the logarithmic (base 10) concentration provoking 5 coughs was recorded.

PROCEDURE

Methacholine Challenge

A baseline spirometry was used to assess how well the participant's lungs work by measuring how much air was inhale, how much was exhale and how quickly the participant exhaled. If this was normal, the subject inhaled slowly and deeply the methacholine test solution from a nebulizer and was told to hold their breath for 5 seconds. This was repeated until 5 inhalations were performed in no more than two minutes.

Sponsors & Collaborators

  • University of Manchester

    collaborator OTHER

  • Mayo Clinic

    lead OTHER

Principal Investigators

  • Kenneth R. DeVault, MD · Mayo Clinic

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-12-31
Primary Completion
2016-02-29
Completion
2016-02-29

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01777867 on ClinicalTrials.gov