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GI Reflux in Lung Transplant and Its Relationship to Chronic Rejection

NCT00455078 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2013-09-05

No results posted yet for this study

Summary

Recent data has suggested that GER (gastric reflux) may worsen after lung transplantation and potentially increase the risk of chronic rejection (CR) after lung transplantation.

The purpose of this study is to look at how often GER occurs in the lung transplant population and examine how GER may change the immune system and cause CR. In this way, we would be able to better identify patients that may benefit from anti-reflux procedures.

Conditions

  • Gastroesophageal Reflux

Interventions

PROCEDURE

esophagogastroduodenoscopy

EGD will be done pretransplant then again before 18mos post transplant.

OTHER

Standard GER questionnaire (RDQ)

RDQ questionnaire will be done pretransplant then again before 18mos post transplant.

PROCEDURE

Scintigraphic evaluation of solid gastric emptying

Scintigraphic evaluation of solid gastric emptying will be done pretransplant then again before 18mos post transplant.

PROCEDURE

Twenty-four hour ambulatory pH testing

Twenty-four hour ambulatory pH testing will be done pretransplant then again before 18mos post transplant.

PROCEDURE

Esophageal manometry testing

Esophageal manometry testing will be done pretransplant then again before 18mos post transplant.

Sponsors & Collaborators

  • University of Chicago

    lead OTHER

Principal Investigators

  • Sangeeta M. Bhorade, MD · University of Chicago

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-06-30
Primary Completion
2010-01-31
Completion
2010-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00455078 on ClinicalTrials.gov