Is the AMH Intrafollicular Level a Predictor of the Ploidy Status of the Blastocyst?

Summary

To investigate, whether on the day of egg retrieval, after ovarian stimulation for ICSI (intracytoplasmic sperm injection), there is a correlation between the intrafollicular AMH (Anti-Müllerian hormone) levels and the ploidy status of the blastocyst.

Conditions

• Infertility, Female
• Infertility

Interventions

PROCEDURE

Oocyte Pick Up - Out of Study

Aspiration of follicles. search for the oocyte(s) All oocytes are grouped in one dish.

PROCEDURE

Denudation - Out of Study

All oocytes are denuded together. Maturational stages are recorded.

PROCEDURE

ICSI

One oocyte injected at a time.

PROCEDURE

Culture

One embryo per culture drop. Individual follow-up of the embryo development.

GENETIC

Biopsy

One embryo per culture drop.

PROCEDURE

Vitrification

One embryo per vitrification straw.

PROCEDURE

OPU - Study Group

Measure the size of the follicle and aspirate only one follicle and flush. The needle before moving to the second ovary. Oocyte included in the study will be cultured separately (each ovary separately too).

PROCEDURE

Denudation - Study Group

Oocyte included in the study will be denuded separately. Maturational stages are recorded per follicle.

Sponsors & Collaborators

• ART Fertility Clinics LLC

  lead OTHER

Principal Investigators

• Laura Melado, PhD · ART Fertility Clinics LLC

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-05-23

Primary Completion

2026-12-01

Completion

2026-12-31

Countries

• United Arab Emirates

Study Locations