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Cumulus Cell Mitochondrial Activity as a Non-invasive Marker of Embryo Quality (FLIM)

NCT05332769 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-03-18

No results posted yet for this study

Summary

This study aims to test the extent of association of FLIM parameters of cumulus cells with clinical outcomes (clinical pregnancy, ongoing pregnancy at 12 weeks, and live birth) of the embryos that result from the enclosed oocytes.

Conditions

  • IVF/ICSI
  • Frozen Embryo Transfer
  • Cumulus Cell
  • Fluorescence Lifetime Imaging Microscopy

Interventions

GENETIC

FLIM parameters

Cumulus samples (CCs) will be collected following the protocol on the day of oocyte pick up (OPU). CCs are frozen by the cryo-tech method, then stored in liquid nitrogen at -196oC. Information of CC samples and processed date/time is recorded. After all, samples are collected, they will be transferred to The Needleman Lab, Northwest Lab Building 359,52 Oxford Street Cambridge MA 02138 to measure mitochondria metabolism using FLIM.

Sponsors & Collaborators

  • The Needleman Lab, Northwest Lab Building 359,52 Oxford Street Cambridge MA 02138.

    collaborator UNKNOWN

  • Harvard University Faculty of Medicine

    collaborator OTHER

  • Hospital Foch, Suresnes, France.

    collaborator UNKNOWN

  • Mỹ Đức Hospital

    lead OTHER

Principal Investigators

  • Tuong M Ho, MD, MCE · Mỹ Đức Hospital

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-25
Primary Completion
2026-05-30
Completion
2026-12-30

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05332769 on ClinicalTrials.gov