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Influence of Gender on Interaction of Propofol and Dexmedetomidine

NCT02853864 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2018-01-31

No results posted yet for this study

Summary

The purpose of this study is to determine the effect of gender on pharmacodynamic interaction of propofol and dexmedetomidine, exploring the effect of gender on propofol unconsciousness median effective concentration with different dose dexmedetomidine.

Conditions

  • Anesthesia

Interventions

DRUG

0.0 ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.0 ng/ml

DRUG

0.4 ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.4 ng/ml

DRUG

0.6 ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.6 ng/ml

DRUG

0.8 ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.8 ng/ml

DRUG

Propofol

The propofol infusion was started to provide an effect-site concentration of 1.0 ug/ml, and increased by 0.2 ug/ml until loss of consciousness

Sponsors & Collaborators

  • Guangzhou General Hospital of Guangzhou Military Command

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2016-12-31
Completion
2016-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02853864 on ClinicalTrials.gov