Pulmonary embolism is an acute obstruction of pulmonary arteries, usually by thrombus, that can cause dyspnea, chest pain, right heart strain, and sudden death if severe.
A study finds end-to-side anastomosis for Crohn’s disease may reduce endoscopic recurrence, while global data show early-onset colorectal cancer has the highest GI cancer burden in young adults, with rising incidence. Both studies highlight evolving challenges and treatment options in gastroenterology.
Cadrenal Therapeutics received FDA guidance for a pivotal Phase 3 trial of CAD-1005 in HIT after an End-of-Phase 2 meeting. Phase 2 data showed a >25% absolute reduction in thrombotic events. The company also plans a Phase 2a trial in cardiac surgery-associated AKI.
The U.S. cardiovascular drugs market is projected to reach $37.03 billion by 2035, growing at a CAGR of 2.68%. Europe's anticoagulants market is expected to reach $23.68 billion by 2033, expanding at a CAGR of 8.22%.
The FDA has approved labeling changes to six menopausal hormone therapy products, removing boxed warnings related to cardiovascular disease, breast cancer, and probable dementia that had been in place since 2003.
The FDA approved pembrolizumab (Keytruda) and Keytruda Qlex plus paclitaxel, with or without bevacizumab, for adults with PD-L1+ platinum-resistant ovarian carcinoma based on Phase 3 trial data showing improved survival outcomes.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07728448 |
Predictors of Pulmonary Embolism in Interstitial Lung Disease With Worsening Symptoms |
NOT_YET_RECRUITING | |
| NCT07689136 |
Timing of Thromboprophylaxis After Postpartum Hemorrhage |
COMPLETED | |
| NCT07659106 |
Decision Aid for Anticoagulation Duration After Unprovoked Venous Thromboembolism |
NOT_YET_RECRUITING | NA |
| NCT07647497 |
Risk Stratification and Prognostic Value of Right Ventricular Dysfunction Screening Using Transthoracic Echocardiography in Acute Pulmonary Embolism |
RECRUITING | |
| NCT07641400 |
Pulmonary Artery Pressure in Predicting Pulmonary Embolism in Patients Presenting To The Emergency Department With Dyspnea |
NOT_YET_RECRUITING | |
| NCT07603700 |
STRATEGY-PE: Real-World Treatment Strategies for Intermediate-High Risk Pulmonary Embolism |
NOT_YET_RECRUITING | |
| NCT07381712 |
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for Acute Respiratory Failure in Pulmonary Embolism. |
ACTIVE_NOT_RECRUITING | NA |
| NCT07356908 |
Impact of Sleep Related Breathing Disorders on Outcomes of Acute Pulmonary Embolism |
COMPLETED | |
| NCT07350499 |
Aspiration Thrombectomy Using the Symphony or Prodigy System |
RECRUITING | |
| NCT07313501 |
Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department |
RECRUITING |
