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Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery

NCT01098409 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2010-04-02

No results posted yet for this study

Summary

The purpose of this study is to determine whether sodium nitrite administration 24 hours prior to or during coronary artery bypass surgery protects the heart better from lack of blood flow which occurs as part of this type of operation. The study will also determine what the mechanisms of this cardioprotection are.

Conditions

  • Coronary Artery Bypass Surgery

Interventions

DRUG

sodium nitrite

0.2mcg/kg/min or 1mcg/kg/min intravenous for 30minutes at 1ml/min

DRUG

0.9% sodium chloride

intravenous 0.9% sodium chloride over 30minutes at 1ml/min

Sponsors & Collaborators

  • University Hospital Birmingham NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Michael P Frenneaux, MD · University of Aberdeen

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2012-01-31
Completion
2012-07-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01098409 on ClinicalTrials.gov