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Myocardial Work and Metabolism in CRT

NCT02537782 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2020-01-09

No results posted yet for this study

Summary

Several attempts have been made to refine selection criteria for cardiac resynchronisation therapy (CRT) in heart failure patients with reduced ejection fraction (HFrEF). Previously proposed parameters probably do not sufficiently reflect the underlying mechanical dyssynchrony of the left ventricle (LV). Earlier work of our research group suggests that better candidate selection can rely on the direct observation or measurement of this LV mechanical dyssynchrony by means of non-invasive imaging. In this study apical rocking and other non-invasive measures of LV mechanical dyssynchrony will be applied to evaluate regional myocardial workload and metabolism, and determine their predictive value in CRT response.

Conditions

Interventions

DEVICE

Cardiac resynchronisation therapy

OTHER

Echocardiography

OTHER

Magnetic Resonance Imaging

OTHER

Positron Emission Tomography

Sponsors & Collaborators

  • Oslo University Hospital

    collaborator OTHER

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Jens-Uwe Voigt, MD, PhD · Universitaire Ziekenhuizen KU Leuven

  • Otto A Smiseth, MD, PhD · Oslo University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2018-12-01
Completion
2023-12-01

Countries

  • Belgium
  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02537782 on ClinicalTrials.gov